Product Category: Immunology

The Immunology Specialists

Immunology is a major focus for Cambridge Bioscience. We are pleased to represent some of the leading specialist immunology reagent manufacturers; including:

Cambridge BioScience is also proud to sponsor the British Society for Immunology.

Markers for Dendritic Cells

Subtypes of dendritic cells (DCs) can be identified according to their localization, phenotype, and immune function. Dendritics specialise the the prodution of mAbs against DC related antigens.

• Langerhans cell Markers
• Interstitial DC Markers
• Plasmacytoid DC Markers

All antibodies are available in the basic purified format in addition to Alexa-488, Alexa-546 or biotin conjugates.
Click here for a full list of Dendritic Cell Markers 

Toll-Like Receptors

At least 11 TLR's have been identified in humans and 13 in mice. Cambridge Bioscience supplies Abs, flow cytometry validated sampler kits, TLR ligands and TLR agonists to allow you to research the full spectrum of TLR's.

• Antibodies for TLR1 to TLR13
• Abs Validated for flow cytometry, IHC (paraffin), IHC (frozen)
• Antibody sampler kits for flow cytometry, (TLR1-9)
• CpG-DNA's for TLR9 research

Find out more

Immune Tolerance- Antibodies For The PD-1 Pathway

The program death 1 receptor (PD-1, also known as CD279) in an inhibitory receptor that plays a key role in peripheral tolerance and autoimmune disease. PD-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) in the cytoplasmic region.

CD279/PD-1 is expressed predominantly on activated T cells, B cells, and the myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279/PD-1 and are members of the B7 gene family.

Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on same normal tissue and upregulation on activated antigen-presenting cells. Interaction of CD279: PD-Ligands result in inhibition of T cell proliferation and cytokine secretion.

Validated and Convenient TLR/NFkB/SEAPorter Transfected Cell Lines

The cell lines are ideal in the study of innate immune pathway activation and as positive controls for TLR phenotyping.

• Validated for expression by western blot and flow cytometry
• Functional validation carried out via ligand response assays
• Optimised format for immediate use

Imgenex have a wide range of agonist molecules for use with the cell lines in their TLR System range and NFkB activation levels can be detected by their NFkB SEAPorter Assay.