Calcium Channel Cell Lines
Cambridge Bioscience, through our collaboration with B'SYS, offers access to a range of stably replicating, validated voltage gated calcium channel cell lines including:
Gene Name: CACNA1C/CACNB2/CACNA2D1
Description: The human CACNA1C gene encodes the pore-forming subunits of Cav1.2. CACNB2 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. Cav1.2 channels are expressed in heart, smooth muscle, neurons and endocrine tissue and are therapeutic targets in cardiac arrhythmia and hypertension.
Gene Name: CACNA1A/CACNB3/CACNA2D2 or CACNA2D4
Description: The human CACNA1A gene encodes the pore-forming subunit of Cav2.1, the voltage-gated P/Q-type calcium channel. CACNB3 and CACNA2D2 or D4 encode auxiliary subunits that modulate gating and pharmacological characteristics. Mutations in CACNA1A are responsible for several inherited neurologic disorders including familial hemiplegic migraine, episodic ataxia type2, and spinocerebellar ataxia type 6 epilepsy. Cav2.1 channels expressed in neurons are therapeutic targets in pain management.
Gene Name: CACNA1G
Description: The human CACNA1G gene encodes the pore-forming subunit of Cav3.1, a voltage-gated T-type calcium channel. Cav3.1 channels are expressed in neuronal cell membranes and may have roles in epilepsy, pain sensing and cardiac pacemaking.
Gene Name: CACNA1H
Description: The human CACNA1H gene encodes the pore-forming subunit of Cav3.2, a voltage-gated T-type calcium channel. Mutations in CACNA1H have been linked to inherited neurologic diseases including idiopathic, generalized and childhood absence epilepsies. Cav3.2 channels expressed in CNS neurons and non-neuronal tissues (sinoatrial node, atrioventricular node, kidney, liver, and vascular endothelium) are therapeutic targets in seizures, hypertension, angina, neuropathic pain, insomnia, and cancer.
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To discuss the purchase of a calcium channel cell line or our custom screening services, please contact our B'SYS specialist Here