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High Performance Gel & Blot Imaging Systems
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Automated Cell Imaging System - JuLIStage

Gel & Blot Imaging Systems - cSeries

Gels and Western blots are the cornerstones of investigations in a wide range of fields; however they often involve complex or slow staining and imaging processes that depend on trial and error for the best images.

Cambridge Bioscience introduces a range of imaging systems for documenting and analysing DNA and protein gels and Western blots using UV, visible light, chemiluminescence and visible/infrared fluorescence. With a market leading range of visualisation capabilities, the Azure Biosystems cSeries imaging systems enables labs to replace transilluminators, gel imagers and darkrooms with one high performance, small, upgradeable, multi-functional instrument. With a dual focussed camera, these systems ensure a sharp image is taken every time, for accurate detection of both low and high concentration targets.

Imaging Benefits Of Using The cSeries Systems
The cSeries offers a range of imaging advantages over other gel and blot visualisation methods and devices:
Broad spectrum of wavelengths visualised - UV to IR
Features dual band UV, EPI-blue & EPI-white light as well as chemiluminescent detection, visible & infrared fluorescence capabilities
High functional dynamic range - more bands visible without saturation
A sensitivity equivalent to film, with a higher dynamic range, ensures good images of both low & high abundance targets
Fast, high quality IR blot images obtained
Carefully selected infrared laser wavelengths provide excitation light much closer to standard dye peaks, improving fluorescence & reducing exposure time dramatically
No focusing
Regardless of the size of your gel, all images are in focus without needing to adjust the focus
No positioning
No matter where you place the sample in the imager, the system will capture it
Crisp, publication quality images taken
The dual focus, up to 8.3MP camera means that images are always sharply focussed & have sufficient resolution for publication & presentation
Internal imaging components optimised
Motorised, wide aperture lens combined with Peltier cooled CCD, 16 bit A/D conversion & optional pixel binning maximises image capture speed & sensitivity

Experimental Benefits Of Using The cSeries Systems
The cSeries offers a range of experimental advantages over other gel and blot visualisation methods and devices:
DNA imaged with minimal damage
Wavelength appropriate to needs can be chosen with the dual band (302 nm and 365 nm) multiple-LED UV tray; longer wavelengths mean less damage
Multiple targets probed on a single blot
Up to three visible or two IR fluorescent channels can be used simultaneously, making co-migration or densitometry studies easy & saving time & reagents
Bands excised without leaving the imager
An override switch for the UV interlock, along with a roll out tray, turns the imaging system into a transilluminator at the touch of a button

Usage Benefits Of Using The cSeries Systems
The cSeries offers a range of usage advantages over other gel and blot visualisation methods and devices:
In situ upgrade capable
Upgrade kits allow the instrument to expand its capabilities as researcher needs grow
Single, small footprint
The cSeries can replace transilluminators, darkrooms & gel imagers with a single, small footprint, benchtop instrument reducing space requirements
UV/laser exposure risks reduced
Safety interlocks disable the lasers & ultraviolet LEDs when the chamber door is opened
Existing protocol compatible
The cSeries instruments are compatible with a wide range of visible, UV responsive or fluorescent probes (see below for a list)
Images taken when it’s convenient
The lifespan of fluorescent dyes means blots can be imaged & reimaged over weeks, with no appreciable loss of signal
Chemiluminescent imaging window extended
High CCD sensitivity & speed improves target detection even when signals are faint or fading

AzureSpot Software
Each of the Azure cSeries systems includes AzureSpot software. Including a suite of analysis tools and a range of output options, this software offers many features including:
Digitally isolating lanes & bands
Automatic lane & band detection that even works on distorted gels
Identifying & quantifying targets
Molecular weight & concentration simply & accurately determined using defined standards & the in-software calibration
Compensating for various types of background
With a few clicks, background can be removed from quantifications
Exporting & transmitting data
Export images, reports & data to TIFF, JPEG, PDF or Excel. Transmit it via Wi-Fi, Ethernet & USB.

AzureSpot Software Processing Views

Compatible Probes
Probes that are compatible with the cSeries are found in the table below. This list is not exhaustive, but contains some of the more common dyes, stains and fluors the cSeries can visualise. The exact list depends on your system configuration:

Material Available For Download
Imaging In-Gel Fluorescence & Stain-Free™ Gels Application Note
Stain-Free™ Gels for Western Blotting: Imaging & Total Protein Normalisation Application Note
Imaging Three-color Western Blots Application Note
Chemiluminescent & Fluorescent Westerns Application Note
Western Blot Normalisation

Organise an Azure cSeries Demonstration
To organise a free demonstration, technical presentation or to find out more, please contact one of our cSeries specialists by Clicking Here

Azure cSeries Citation List

Alexa Fluor, SYBR and SYPRO are registered trademarks of Molecular Probes Inc. Coomassie is a registered trademark of ICI. Cy is a registered trademark and Deep Purple and ECL Plex are trademarks of GE Healthcare Ltd. DyLight and Qdot are registered trademarks of Thermo Fisher Scientific Inc and its subsidiaries. GelStar is a registered trademark of FMC Corporation. IRDye is a registered trademark of LI-COR Inc.

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