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Supplier:
Product types:
GLP Compliant Safety Pharmacology Services
ELISA Based Endotoxin Detection Kit
Ion Channel Screening & Profiling Services

hERG Concentration Response Assay

Cambridge Bioscience offers access to an assay service from B’SYS enabling the determination of therapeutic safety margins and proarrhythmic potential. This hERG concentration-response assay (either GLP or non-GLP compliance) is a manual patch clamp assay that determines an IC50 value which, in the context of intended therapeutic levels, provides an important benchmark for cardiac risk assessment. The assay can also be performed at physiological temperature and/or in the presence of human plasma or plasma proteins.

Benefits of Using This hERG Concentration Response Assay
• Quantitative assessment of inhibitory potency
• Physiological temperature available
• Pre-testing options for concentration & solubility
• Concentration verification available
• Three week turnaround time with concentration analysis

Additional Options Available
The following features can be added to the standard project:
• Dose solution analysis – GLP & non-GLP
• Use-dependence analysis – perform assay in presence of human plasma or plasma proteins
• Temperature-dependence analysis
• Additional copies of final report
• Copies of solution worksheets & data-collection forms

Contact Our Specialists
To discuss a hERG concentration response assay project, please contact our B'SYS specialist by Clicking Here

Contact Our B'SYS Specialist, Vashu