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Automated Cell Imaging System - JuLIStage
Luminex and Singulex Assay Miniaturisation

Hypoxic Cell Culture System - Avatar™

Cambridge Bioscience offers the first cell culture system capable of reproducing the physiologically relevant conditions of hydrostatic pressure and low oxygen required to mimic the in vivo environment specific to a sample type. By specifically controlling O2, CO2, hydrostatic pressure, temperature and humidity to recreate the native conditions of a sample, the Avatar cultures samples in an environment best suited to delivering biologically relevant results. These revolutionary capabilities enable the system to culture previously unculturable samples and for the first time provide reliable results with samples cultured using Avatar exhibiting near-native morphology and gene expression.

Benefits of Using Avatar
• Specific control of O2, CO2, hydrostatic pressure, temperature & humidity
• Mimics in vivo environments specific to a sample type
• Produces biologically relevant results
• Produces cells with near-native morphology & gene expression
• < 20 minutes from closure to full calibration
• Consumes 80% less gas than standard hypoxic incubators
• Small footprint & stackable

Applications
The Avatar has been already shown to provide exceptional results in the following applications:
• Cell development
• Metastasis
• Circulating tumour cells
• More applications are in development

Examples of Conditions Created With Avatar

Pancreatic Cell Lines Cultured With Avatar

Pancreatic cancer cell lines (PANC-10) cultured under conditions mimicking the metastatic niche (low oxygen & high pressure) decreases the expression of immunotherapeutic target PD-L1 (right image). Left image: 20% oxygen, 0 psi. Right image: 1% oxygen, 2 psi

Material Available To Download
Avatar Environmental Modeling Application Note
Avatar Immunotherapics Application Note
Avatar Tunable Stem Cell Application Note
Avatar Datasheet
Avatar Peripheral Blood Mononuclear Cell Maintenance and Expansion

Find Out More
Request a technical presentation or find out more by contacting our Avatar specialists Here

Talk To Our Xcell Biosciences Specialist Mike