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P2X Receptor Cell Lines

Cambridge Bioscience, through our collaboration with B'SYS, offers access to a range of stably replicating, validated ionotropic purinergic receptor channel cell lines including:

P2X1
Gene Name: P2RX1
Description: The human P2RX1 gene encodes P2X1, an ionotropic ATP receptor that functions as an ATP- or ADP-activated cation channel, expressed in smooth muscle, platelets, and sensory neurons. A P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced platelet aggregation. P2X1 receptors are therapeutic targets in treatment of urinary incontinence and pain.

P2X4
Gene Name: P2RX4
Description: The human P2RX4 gene encodes P2X4, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in the CNS, alveolar macrophages, vascular endothelium, and airway smooth muscle. P2X4 receptors are therapeutic targets in treatment of neuropathic pain, asthma, and heart failure.

P2X7
Gene Name:
P2RX7
Description: The human P2RX7 gene encodes P2X7, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in lymphocytes and microglia. P2X7 receptors are therapeutic targets in treatment of osteoporosis, neuropathic and inflammatory pain, and immune diseases.

Find Out More
To discuss the purchase of P2X receptor cell line or our custom screening services, please contact our B'SYS specialist Here
Contact Our B'SYS Specialist, Vashu