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How automated cell counters work

Published 3 October 2024 by Aoife Holohan

Enhancing Efficiency with Automated Cell Counters

Automated cell counters have become an essential tool for life science researchers, offering precise results far more quickly than manual cell counting methods. The CellDrop™ systems from DeNovix take the benefits of traditional automated cell counting to the next level, adding a range of usability improvements that streamline the entire process.

By removing the need for disposable plastic slides and optimising workflow efficiency, the CellDrop Automated Cell Counter provides significant cost savings over conventional cell counting and viability testing methods.

In this blog, we’ll delve into the core principles of automated cell counters and highlight the advantages offered by the DeNovix CellDrop system.

Advantages of Automated Cell Counters: A Closer Look

  • Accurate and reproducible automated cell counting and viability testing
  • Elimination of subjective results from manual counting
  • Customisable user-defined protocols for consistency across users and labs
  • Automatic imaging of live and dead cells using image-based analysis
  • Cost reduction through decreased operation time and elimination of slide expenses
  • Increased range of applications
  • Reduction of plastic waste in laboratories

How CellDrop Automated Cell Counters Operate

The CellDrop Automated Cell Counters build upon the core principles of manual cell counting. Samples are stained with a suitable reagent and pipetted into a sample chamber formed between two optical-grade sapphire surfaces. The precise control of the sample chamber’s height and field of view enables accurate volume calculation, ensuring reliable cell counting and viability assessments. After analysis, the sample is easily wiped away with a dry laboratory wipe, making the device ready for the next sample.

The CellDrop series incorporates a unique blend of fluorescence and brightfield optics, paired with a variety of pre-set applications that include default protocols for different assays. The mechanically-adjustable height chamber offers unmatched accuracy across a broad range of cell densities (7 x 10² to 2.5 x 10⁷) and cell sizes (4 to 400 µm). This versatility makes the CellDrop one of the most flexible cell counting instruments on the market.

Automated Cell Counters by DeNovix

As a leading provider of high-quality analytical instruments, DeNovix designs its products with daily usability in mind. If you’re interested in learning more about purchasing or leasing a CellDrop automated cell counter, contact our DeNovix specialists.

Cell counting