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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1181081-71-9
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
307.3
Alternative Names:
(5z)-5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2h)-pyridazinyl)-4(5h)-thiazolone
- Data sheet: View or download
- MSDS: View or download
Product Description:
A KCC2 cotransporter activator (EC50 = 616 nM for chloride transport in NG108-cl cells); selective for KCC2 over GABAA receptors at 50 µM; increases the rate of chloride accumulation in spinal slices isolated from a rat model of PNI and BDNF control slices; increases mechanical withdrawal thresholds in a rat model of PNI and reverses morphine-induced hyperalgesia in rats at 100 mg/kg
Storage Temperature:
-20°C