Ganglioside GD1a (bovine) (ammonium salt)

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A mixture of ganglioside GD1a molecular species with C14:0, C16:0, C18:0, C20:0, and C22:0 fatty acyl chains; a sialic acid-containing glycosphingolipid that has been found in brain, erythrocytes, bone marrow, testis, spleen, and liver, as well as serum lipoproteins; shed into the microenvironment from the surface of tumor cells, where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis; colocalizes with TLR2 and enhances the binding of LT-IIb-B5 to TLR2 at 20 µM; increases VEGF-induced proliferation of HUVECs at 20 µM; induces vascularization in a Matrigel™ plug assay in mice at 20 µM/plug; accumulates in the CNS of patients with galactosialidosis