This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2411085-89-5
Purity:
98.66
Molecular Weight:
774.71
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)