This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2701565-76-4
Purity:
99.71
Molecular Weight:
443.49
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)