This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2230757-47-6
Purity:
98.41
Molecular Weight:
481.51
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)