This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1385035-79-9
Purity:
98.05
Molecular Weight:
701.89
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
GNA002 is a highly potent, specific and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor with an IC50 of 1.1 µM. GNA002 can specifically and covalently bind to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. GNA002 efficiently reduces EZH2-mediated H3K27 trimethylation, reactivates polycomb repressor complex 2 (PRC2)-silenced tumor suppressor genes[1].
Storage Temperature:
-20°C (Powder, stored under nitrogen)