SEC inhibitor KL-1
Catalogue number:
HY-122720-50mg
Supplier:
Size:
50 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
900308-84-1
Purity:
99.38
Molecular Formula:
C18H16ClNO4
Molecular Weight:
345.78
Alternative Names:
KL-1
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 µM[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)