This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2490599-18-1
Purity:
98.98
Molecular Weight:
861.93
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent agent resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)