TED-347
Catalogue number:
HY-125269-50mg
Supplier:
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2378626-29-8
Purity:
98.78
Molecular Weight:
313.7
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 µM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 µM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)