Rheb inhibitor NR1
Catalogue number:
HY-124798-1mL
Supplier:
Size:
1 ml _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2216763-38-9
Purity:
99.46
Molecular Weight:
578.3
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1]. (Rheb-IVK: Rheb-dependent mTORC1 kinase activity)
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)