7,4'-Dihydroxyflavone
Catalogue number:
HY-N2609-50mg
Supplier:
Size:
50 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2196-14-7
Purity:
99.68
Molecular Formula:
C15H10O4
Molecular Weight:
254.24
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)