This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
895158-95-9
Purity:
98.5
Molecular Formula:
C16H11FN6O
Molecular Weight:
322.3
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)