Prexasertib (dimesylate)
Catalogue number:
HY-18174E-25mg
Supplier:
Size:
25 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1234015-58-7
Purity:
99.04
Molecular Formula:
C20H27N7O8S2
Molecular Weight:
557.6
Alternative Names:
LY2606368 (dimesylate)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity[1][2].
Storage Temperature:
4°C (Powder, stored under nitrogen)