AS2863619 (free base)
Catalogue number:
HY-126675-5mg
Supplier:
Size:
5 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2241300-50-3
Purity:
99.87
Molecular Formula:
C16H12N8O
Molecular Weight:
332.32
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)