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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2326521-71-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
604.1
Alternative Names:
(2s)-4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2s)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-2-piperazineacetonitrile
- Data sheet: View or download
- MSDS: View or download
Product Description:
A covalent inhibitor of K-RasG12C; binds to and stabilizes GDP-bound inactive K-RasG12C in an electrophoretic mobility shift assay from 2-15.6 nM; reduces phosphorylation of the K-Ras targets ERK and S6 in MIA PaCa-2 cancer cells from 33-1,000 nM; reduces tumor volume in 17 K-RasG12C-expressing lung, colon, pancreatic, cervical, and esophageal cancer mouse xenograft models at 100 mg/kg
Storage Temperature:
-20°C