Cyclizine (hydrochloride)
Catalogue number:
CAY31190-5 g
Supplier:
Size:
5 g
Product is available in:
POA
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This product is for research use only and is not for human consumption or therapeutic use.
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CAS Number:
303-25-3
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
302.8
Alternative Names:
1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride
- Data sheet: View or download
- MSDS: View or download
Product Description:
A histamine H1 receptor antagonist; binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively); inhibits anti-IgE-induced histamine release from isolated human lung fragments (IC50 = 5.42 µM) but also induces histamine release (RC50 = 10.81 µM); reduces LPS-induced nitrite accumulation and protein levels of iNOS in RAW 264.7 cells at 100 nM; reduces immobility in the forced swim test in rats at 10 and 20 mg/kg
Storage Temperature:
-20°C