RK-287107
Catalogue number:
CAY30998-5 mg
Supplier:
Size:
5 mg
Product is available in:
£348.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2171386-10-8
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
416.5
Alternative Names:
2-[4,6-difluoro-1-(2-hydroxyethyl)spiro[3h-indole-3,4′-piperidine]-1′(2h)-yl]-5,6,7,8-tetrahydro-4(3h)-quinazolinone
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TNKS1 and TNKS2 inhibitor (IC50s = 0.014 and 0.010 µM, respectively); selective for TNKS1 and TNKS2 over PARP1, PARP2, and PARP10 (IC50s = >20, 2.7, and 19.8 µM, respectively); inhibits Wnt-dependent signaling (IC50 = 0.077 µM in a reporter assay); increases Axin2 accumulation in COLO 320DM cells at 0.1 µM; inhibits cell growth in COLO 320DM cells (GI50 = 0.45 µM); reduces tumor growth in a COLO 320DM mouse xenograft model at 150 mg/kg
Storage Temperature:
-20°C