C188-9
Catalogue number:
CAY30928-5 mg
Supplier:
Size:
5 mg
Product is available in:
£113.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
432001-19-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
471.5
Alternative Names:
n-(1′,2-dihydroxy[1,2′-binaphthalen]-4′-yl)-4-methoxy-benzenesulfonamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A STAT3 inhibitor; binds to the STAT3 SH2 domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived AML cells (IC50s = 8-18 µM); induces apoptosis in patient-derived AML cells (EC50s = 6-50 µM); reduces viability of HepG2, Huh7, and PLC/PRF/5 hepatoma cells (IC50s = 10.19, 11.27, and 11.83 µM, respectively); reduces hepatic Pten deletion-induced hepatic macro- and microsteatosis which reduces the development of hepatocellular carcinomas in mice at 100 mg/kg; increases muscle fiber size in a murine Lewis lung carcinoma model of cancer cachexia at 12.5 mg/kg
Storage Temperature:
-20°C