PLX51107
Catalogue number:
CAY30742-5 mg
Supplier:
Size:
5 mg
Product is available in:
£357.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1627929-55-8
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
438.5
Alternative Names:
4-[6-(3,5-dimethyl-4-isoxazolyl)-1-[(1s)-1-(2-pyridinyl)ethyl]-1h-pyrrolo[3,2-b]pyridin-3-yl]-benzoic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A BET family protein inhibitor; binds to BD1 in BRD2, BRD3, BRD4, and BRDT (Kds = 1.6, 2.1, 1.7, and 5 nM, respectively), as well as BD2 (Kds = 5.9, 6.2, 6.1, and 120 nM, respectively); binds to bromodomains of CBP and p300 (Kds = ~100 nM for both); inhibits CpG-induced proliferation of primary CLL cells from 0.1-10 µM; inhibits Ba/F3 cell-induced splenomegaly in mice from 0.5-10 mg/kg; reduces tumor volume and increases survival in YUMM3.3 and D4M3.A mouse syngeneic B-RAFV600E mutant melanoma models
Storage Temperature:
-20°C