4'-O-Methylhonokiol

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A phenol with diverse biological activities; active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml); inhibits LPS-induced activation of NF-kB and production of NO in RAW 264.7 macrophages at 10 and 30 µM; reduces carrageenan-induced paw edema in mice at 20 and 200 mg/kg; reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Aβ42-induced Alzheimer's disease at 1 mg/kg; reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity