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39133-31-8
≥98%
A crystalline solid
387.5
3,4,5-trimethoxy-benzoic acid, 2-(dimethylamino)-2-phenylbutyl ester, (±)-trimebutine
- Data sheet: View or download
- MSDS: View or download
An opioid receptor agonist; It binds to µ-, δ-, and κ-opioid receptors (Kis = 0.34, 0.5, and 0.58 µM, respectively, in canine myenteric plexus synaptosomes) inhibits twitch contraction and ACh release induced by low-frequency electrical stimulation in isolated guinea pig LM-MP (EC50s = 0.274 and 0.215 µM, respectively); increases twitch contraction and ACh release induced by high-frequency electrical stimulation in isolated guinea pig LM-MP at ≤1 µM, but inhibits these effects at ≥10 µM; decreases the amplitude and frequency of spontaneous contractions in isolated guinea pig colonic smooth muscle strips at 30, 100, and 300 µM; inhibits BKCa and L-type calcium currents in colonic smooth muscle cells
-20°C