£691.00
Estimated delivery Fri 2 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
610798-31-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
391.4
Alternative Names:
n-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine, bpi 2009h
- Data sheet: View or download
- MSDS: View or download
Product Description:
An EGFR inhibitor (IC50 = 2 nM); selective for EGFR over Abl, Abl2, and c-Src tyrosine kinases at 1,000 nM; inhibits EGFR-mediated tyrosine phosphorylation in A431 cells (IC50 = 45 nM); inhibits the growth of PC-9 and HCC827 NSCLC cells (IC50s = 50 = 8,800 nM), which do not; inhibits migration of HCC827 cells at 100 nM and increases apoptosis by 43.7% at 10 nM; reduces tumor growth in a variety of mouse xenograft models at 50-120 mg/kg per day
Storage Temperature:
-20°C