£436.00
Estimated delivery Fri 2 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1612888-66-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
413.4
Alternative Names:
3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-benzoic acid, rpt835
- Data sheet: View or download
- MSDS: View or download
Product Description:
An allosteric inhibitor of FGFR2; inhibits FGF2-induced phosphorylation of FRS2α in KATO III cells (IC50 = 10 nM); inhibits the growth of SKOV3 and Hs 578T cells (GI50s = 370 and 210 nM, respectively); inhibits bFGF-induced HUVEC proliferation (IC50 = 11 nM); inhibits SVEC4-10 cell tube formation at 50 nM; decreases the number of tumor microvessels by 50% in a SKOV3 ovarian serous carcinoma mouse model; reduces tumor growth in mouse xenograft models at 30 mg/kg per day
Storage Temperature:
-20°C