£411.00
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
69408-81-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
283.3
Alternative Names:
5-amino-2-[2-(dimethylamino)ethyl]-1h-benz[de]isoquinoline-1,3(2h)-dione, as1413, benzisoquinolinedione, nafidimide, nci 308847, nsc 308847
- Data sheet: View or download
- MSDS: View or download
Product Description:
A DNA-intercalating topoisomerase II poison; reduces the formation of kinetoplast DNA minicircles in a cell-free assay at 100 µM, but does not induce relaxation of supercoiled DNA; inhibits growth in a panel of 11 human cancer cell lines including leukemia, gastric, breast, and lung cancer cells (GI50s = 1-10 µM); induces cell cycle arrest at the G2/M phase and apoptosis in AGS gastric and Huh7 hepatoma cancer cells, respectively, from 2.5-10 µM; reduces primary tumor growth and decreases pulmonary metastasis in a murine H22 hepatoma model at 5 mg/kg
Storage Temperature:
-20°C