Isoalantolactone
Catalogue number:
CAY33838-250 mg
Supplier:
Size:
250 mg _$$_
Product is available in:
£247.00
Estimated delivery Wed 4 Sep
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
470-17-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C15H20O2
Molecular Weight:
232.3
Alternative Names:
(3ar,4as,8ar,9ar)-decahydro-8a-methyl-3,5-bis(methylene)-naphtho[2,3-b]furan-2(3h)-one, (+)-isoalantolactone, nsc 241036
- Data sheet: View or download
- MSDS: View or download
Product Description:
A sesquiterpene lactone with diverse biological activities; inhibits proliferation of PANC-1, BxPC-3, and HPAC pancreatic cancer cells (IC50s = 40, 43, and 48 µM, respectively); induces apoptosis, cell cycle arrest at the S phase, and the production of ROS in PANC-1 cells; decreases LPS-induced production of NO, PGE2, IL-6, and TNF-α in RAW 264.7 macrophages at 4 and 8 µM; reduces production of S. aureus α-toxin in a concentration-dependent manner and increases survival in a mouse model of S. aureus-induced pneumonia at 50 mg/kg
Storage Temperature:
-20°C