£375.00
Estimated delivery Fri 2 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1876467-74-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
375.4
Alternative Names:
2-[(3r)-3-methyl-4-morpholinyl]-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-3-yl)-1,7-naphthyridine, elimusertib
- Data sheet: View or download
- MSDS: View or download
Product Description:
An ATR inhibitor (IC50 = 7 nM); selective for ATR over DNA-PK, ATM, and PI3Kβ (IC50s = 0.332, 1.42, and 3.27 µM, respectively); inhibits proliferation of HT-29 and LoVo colorectal cancer cells and SU-DHL-8 B lymphoma cells (IC50s = 0.16, 0.071, and 0.009 µM, respectively); reduces tumor growth in a mutant ATMK1964E-containing SU-DHL-8 and LoVo mouse xenograft models at 50 mg/kg; synergistic with carboplatin, olaparib, or radiation in various mouse xenograft models
Storage Temperature:
-20°C