Meglutol
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503-49-1
≥95%
A solid
1499
3-hydroxy-3-methyl-pentanedioic acid, 3-hydroxy 3-methyl glutaric acid, 3-hydroxy-3-methylglutaric acid, 3-methyl-3-hydroxyglutaric acid, cb 337, dicrotalic acid, hmg, medroglutaric acid, nsc 361411
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- MSDS: View or download
An HMG-CoA reductase inhibitor (IC50 = 4 nM); dietary administration reduces serum total cholesterol levels in normal rats; reduces serum total cholesterol levels in high-cholesterol fed and hypercholesterolemic rats at 50 mg/kg per day; reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet at 25 mg/animal per day; ) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups at 0.5 µmol/g, i.c.v.
-20°C