£844.00
Estimated delivery Fri 23 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2249435-90-1
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C25H19FN2O4S
Molecular Weight:
462.5
Alternative Names:
n-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-[1,1′-biphenyl]-4-carboxamide, gun35901
- Data sheet: View or download
- MSDS: View or download
Product Description:
A STING antagonist; binds to the STING cyclic dinucleotide binding site (Kd = 4.03 nM) and inhibits 2'3'-cGAMP-induced Ifnb expression in MEFs, BMDMs, and HFFs (IC50s = 127.5, 107.1, and 502.8 nM, respectively); impairs recruitment of IRF3 or TBK1 to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits HSV-1-induced translocation of STING from the ER to the Golgi at 1 µM; increases survival and reduces Ifnb mRNA levels in the Trex1-/- mouse model of Aicardi-Goutières syndrome at 5 mg/kg
Storage Temperature:
-20°C