£1535.00
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1103522-45-7
Purity:
≥98%
Formulation:
A solid
Molecular Formula:
C16H14Br2N6O4S
Molecular Weight:
546.2
Alternative Names:
n-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-sulfamide, act-132577
- Data sheet: View or download
- MSDS: View or download
Product Description:
A dual ETA and ETB receptor antagonist and an active metabolite of macitentan; inhibits ET-1- induced increases in intracellular calcium in HPASMCs (IC50 = 14 nM), ET-1-induced contractions in isolated rat aortic rings (pA2 = 6.7 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pKB = 5.5 for ETB); reduces ET-1-induced increases in proliferation of isolated human skin fibroblasts at 10 and 100 µM; increases plasma ET-1 concentrations in normotensive rats and decreases MAP in DOCA-salt hypertensive rats at 10-300 mg/kg
Storage Temperature:
-20°C