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CC-92480

Catalogue number:
CAY31065-5 mg
Supplier:
Size:
5 mg
Product is available in:
  • UK
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£553.00 Estimated delivery Wed 24 Dec
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

2259648-80-9

Purity:

≥98%

Formulation:

A solid

Molecular Formula:

C32H30FN5O4

Molecular Weight:

567.6

Alternative Names:

4-[4-[[4-[[[2-[(3s)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-1h-isoindol-4-yl]oxy]methyl]phenyl]methyl]-1-piperazinyl]-3-fluoro-benzonitrile, ​mezigdomide

Product Description:

A cereblon modulator; binds to cereblon (IC50 = 0.03 µM in a FRET assay) and induces the degradation of Ikaros and Aiolos in H929 R10-1 at 1, 10, and 100 nM; induces apoptosis in the same cells; reduces tumor growth in an H929 R10-1 mouse xenograft model at 1, 3, and 10 mg/kg