BI-9627 (hydrochloride)
Catalogue number:
HY-18071A-1ml
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1422252-46-7
Purity:
98.47
Molecular Weight:
392.8
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)