FzM1.8
Catalogue number:
HY-117163-1ml
Supplier:
Size:
1 ml
Product is available in:
CAS Number:
2204290-85-5
Purity:
98.37
Molecular Weight:
322.31
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)