This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
106400-81-1
Purity:
98.02
Molecular Weight:
443.45
Alternative Names:
DDATHF
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)