Aurintricarboxylic acid
Catalogue number:
HY-122575-1ml
Supplier:
Size:
1 ml _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
4431-00-9
Purity:
92
Molecular Weight:
422.34
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively[1]. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase[2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis[3]. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway[4]. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 µM[5]. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM[6].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)