Pactimibe (sulfate)
Catalogue number:
HY-100401A-1ml
Supplier:
Size:
1 ml _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
608510-47-0
Purity:
98.22
Molecular Formula:
C25H40N2O3.1/2H2O4S
Molecular Weight:
465.65
Alternative Names:
CS-505
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 µM and 3.0 µM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 µM, 2.7 µM, 4.7 µM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 µM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 µM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)