This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2519823-34-6
Purity:
99.62
Molecular Formula:
C40H49ClN8O8S
Molecular Weight:
837.38
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162)[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)