This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2705844-82-0
Purity:
98.4
Molecular Formula:
C48H44ClFN8O11
Molecular Weight:
963.36
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)