This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2209085-22-1
Purity:
99.82
Molecular Formula:
C53H69N5O9
Molecular Weight:
920.14
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)