This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2896737-31-6
Purity:
99.16
Molecular Formula:
C102H160N27F3O30
Molecular Weight:
2301.55
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS[1].
Storage Temperature:
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)