IN-1130
Catalogue number:
HY-18758-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
868612-83-3
Purity:
99.79
Molecular Weight:
420.47
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 µM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)