This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
189198-30-9
Purity:
98.07
Molecular Weight:
416.6
Alternative Names:
CS-505 (free base)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 µM and 3.0 µM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC50s of 2.0 µM, 2.7 µM, 4.7 µM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 µM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 µM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)