This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1426953-21-0
Purity:
98
Molecular Weight:
535.63
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC[1][2][3].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)