This product is for research use only and is not for human consumption or therapeutic use.
Purity:
98.01
Molecular Weight:
694.7
Alternative Names:
PR-957 (TFA)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 µM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)